在患有血管疾病的个体中,摄入量和发生心房动

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Updated: Jun 21, 2025

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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

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Linda S Johnson^1,2, Andrew Mente², Philip Joseph²

¹Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden.

JAMA network open

|July 11, 2024

概括

高摄入量与心血管疾病或糖尿病患者心房动 (AF) 风险增加有关. 减少的摄入量,特别是那些摄入量高的人,可能有助于预防AF.

科学领域:

心血管医学心血管医学
腎臟病學 (nephrology) 是一種醫學.
流行病学流行病学

背景情况:

前性队列研究经常报告尿液分泌与心血管事件/死亡之间的J形关联.
了解摄入量与心房动 (AF) 之间的特定关系对于心血管健康管理至关重要.

研究的目的:

调查估计每日摄入量与心房动 (AF) 发生率之间的关联.
确定高风险人群中消耗水平和AF风险之间是否存在J形关系.

主要方法:

利用了来自ONTARGET和TRANSCEND试验中27,391名患有血管疾病或高风险糖尿病的参与者的数据.
估计每日摄入量使用川崎配方从早晨的禁食尿样.
采用多变量调整的考克斯回归和立方斜线来建模摄入量和事件AF之间的关联,平均随访时间为4.6年.

主要成果:

在摄入量和AF风险之间观察到J形关联 (非线性P = .03).
8g/d或更高的摄入量与与4-5.99g/d相比,增加了32%的发生性AF风险.
超过6g/d的摄入量显示每增加1g/d的AF风险增加10%,而较低摄入量水平没有进一步降低风险.

结论:

这项队列研究证实了心血管疾病或糖尿病患者的摄入量和AF风险之间的J形关联.
旨在降低AF预防的摄入量的干预措施应优先考虑饮食中摄入量高的个体.
这些发现表明,针对高饮食是减少与相关的AF风险的最有效策略.

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