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肝细胞癌的免疫检查点抑制剂治疗期间肝功能的演变

Katharina Pomej^1,2, Lorenz Balcar^1,2, Sabrina Sidali³

¹Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.

United European gastroenterology journal

|July 11, 2024

概括

免疫检查点抑制剂 (ICI) 可以改善或稳定晚期肝细胞癌 (HCC) 患者的肝功能. 这种肝功能改善与更好的生存结果有关,即使对于那些在基线时患有Child-Pugh类B的人来说.

科学领域:

肝病学肝病学是一种肝病学.
在瘤学瘤学.
免疫治疗是一种免疫疗法.

背景情况:

肝功能恶化是晚期肝细胞癌 (HCC) 死亡的主要原因.
免疫检查点抑制剂 (ICI) 越来越多地用于HCC治疗,但它们对肝功能的影响需要评估.

研究的目的:

评估ICI治疗对晚期HCC患者肝功能的影响.
确定肝功能变化与患者的治疗结果 (包括生存时间) 之间的相关性.

主要方法:

对接受ICI或索拉芬尼布治疗的HCC患者的回顾性分析.
在基线,治疗开始后3个月和6个月使用Child-Pugh评分 (CPS) 评估肝功能.
在CPS的变化被分类为改善,稳定或恶化.

主要成果:

在182名ICI治疗患者中,56%的患者在3个月后表现出改善或稳定的肝功能,45%的患者在6个月后表现出改善或稳定的肝功能.
对ICI的放射性反应与肝功能改善/稳定相关 (73%对50%).
6个月后肝功能改善/稳定与总体存活率显著改善 (28.4 vs 14.2个月) 相关.
在基线Child-Pugh类B的患者中,46%的肝功能在3个月后得到改善或稳定,有些人过渡到Child-Pugh类A.

结论:

在晚期HCC中,ICI治疗可以使肝功能稳定或改善.
放射性反应和改善的肝功能与增强的生存率有关.
这些好处甚至在最初被归类为Child-Pugh类B的患者中也被观察到.

关键词:

肝细胞癌是肝细胞癌.免疫检查点抑制剂免疫检查点抑制剂肝癌肝癌是一种肝癌.肝硬化是肝硬化的一种疾病.肝功能肝功能肝功能索拉芬尼布 (Sorafenib) 是一个

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