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在转移性皮肤黑色素瘤中,基线透瘤的淋巴细胞模式和对免疫检查点抑制的反应

Isabella A J van Duin¹, Mark Schuiveling¹, Laurens S Ter Maat²

¹Department of Medical Oncology, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CG Utrecht, the Netherlands.

European journal of cancer (Oxford, England : 1990)

|July 11, 2024

概括

转移性黑色素瘤中的瘤透淋巴细胞 (TIL) 预测免疫检查点抑制 (ICI) 的反应. 在H&E幻灯片上较高的TIL独立地与更好的客观反应率,无进展生存率和晚期黑色素瘤患者的整体生存率相关.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
病理学病理学病理学

背景情况:

瘤透淋巴细胞 (TILs) 与黑色素瘤的存活率有关.
对于免疫检查点抑制 (ICI) 反应的TILs的预测价值尚不清楚.
这项研究研究了TILs作为ICI响应在晚期黑色素瘤中的生物标志物.

研究的目的:

评估在接受一线ICI的晚期黑色素瘤患者中TIL和治疗反应之间的关联.
确定TIL是否是一种独立的反应预测指标,并根据临床因素进行调整.

主要方法:

针对使用抗PD1±抗CTLA4.4治疗的晚期黑色素瘤患者的多中心队列研究.
在使用验证方法 (TILs-WG,Clark,MIA) 的初级和转移性瘤的H&E幻灯片上得分的TILs.
客观反应率 (ORR),无进展生存率 (PFS) 和整体生存率 (OS) 通过逻辑回归和Cox比例危险模型进行了分析.

主要成果:

在初级黑色素瘤样本中,没有发现TILs和响应之间的关联.
在转移样本中,较高的TILs-WG得分与增加的ORR (aOR 1.17),改善的PFS (HR 0.93) 和更长的OS (HR 0.94) 相相关.
与最低的三位数相比,具有最高TILs三位数的患者显示PFS和OS显著更长.

结论:

在治疗前转移性黑色素瘤转移中的TIL模式是ICI反应的独立预测因素.
在H&E幻灯片上进行TIL评估是临床使用的实用生物标志物.
这些发现支持TILs在指导晚期黑色素瘤治疗决策中的实用性.

关键词:

免疫检查点抑制抑制黑色素瘤是一种黑色素瘤.响应响应响应响应透到瘤的淋巴细胞

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