在治疗抑郁症的凯胺输注期间血压变化
Mina Ansari1, Brian Pittman2, Daniel S Tylee2
1Yale Depression Research Program (YDRP), Yale University, New Haven, CT 06511, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
治疗抑郁症的胺注射可以增加血压,特别是在老年患者和有过高血压病史的人群中. 仔细监测是治疗期间管理这些心血管风险的关键.
科学领域:
- 精神病学和神经病学的精神病学和神经病学
- 心血管医学 心血管医学
背景情况:
- 胺越来越多地用于治疗耐药性抑郁症.
- 了解其对心血管的影响,特别是血压变化,对于患者的安全至关重要.
研究的目的:
- 为了分析抑郁症胺注射期间血压 (BP) 波动.
- 为了确定与显著的血压变化和高血压事件相关的患者特异性因素.
主要方法:
- 在7年内对138名接受胺注射的患者进行了回顾性图表审查.
- 在输液过程中,每10分钟记录一次血压.
- 与人口统计和病史相关的压缩性 (SBP) 和压缩性 (DBP) 血压升和严重高血压的分析.
主要成果:
- 在注射40分钟后,SBP和DBP达到峰值 (平均增加分别为16.0mmHg和11.0mmHg).
- 严重的高血压发生在12.5%的患者中,在早期输液期间更频繁.
- 高龄和高血压史与增加的SBP和BP升有显著的关联.
结论:
- 胺注入与血压显著增加有关,尽管往往是短暂的.
- 患有先前高血压的患者和老年人需要在胺治疗期间加强心血管监测.
- 积极的风险管理策略是必要的,以确保对抑郁症安全使用胺.
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