在患有罗兰迪的儿童中,个体性形态大脑网络的变化
Yu Yin1, Xiaofan Qiu2, Lisha Nie3
1Department of Radiology, Affiliated Hospital of Zunyi Medical University, Medical Imaging Center of Guizhou Province, Engineering Research Center of Intelligent Medical Imaging in Guizhou Higher Education Institutions, Zunyi 563003, China; Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha 410011, China.
患有罗兰特 (RE) 的儿童表现出大脑结构的改变和大脑网络的破坏. 这些发现表明,网络层面的变化是可再生能源的关键.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 的研究研究.
背景情况:
- 罗兰特 (RE) 是一个常见的儿童综合征.
- 了解RE中潜在的大脑结构和网络变化对于诊断和治疗至关重要.
研究的目的:
- 研究RE儿童的局部皮质形态学和基于个体的形态脑网络 (MBNs).
- 为了比较RE和健康对照 (HC) 的儿童之间的MBN.
主要方法:
- 分析了56名RE和56名HC儿童的结构MRI数据.
- 四种类型的MBN是使用皮层厚度,碎形维度,化指数和深度来构建的.
- 图形理论被应用于分析全球和节点网络属性.
主要成果:
- 患有RE的儿童表现出右后带带状回路的旋转指数增加,右前带状回路和中间前额皮层的深度增加.
- 在基于CT和FD的网络中,RE显示了特征路径长度的增加.
- 在RE患者的右下额头环中观察到基于FD的网络节点效率下降.
结论:
- 患有RE的儿童表现出被破坏的形态大脑网络组织,超出局部变化.
- 这些发现提供了对RE的神经病理机制的见解.
- 进一步的研究可以探索这些网络变化的临床影响.
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