在初级渐进性失言症变体中的网络中断和网络中断之间的语音语言
Neha Singh-Reilly1, Hugo Botha1, Joseph R Duffy1
1Department of Neurology, Mayo Clinic, Rochester, MN, USA.
NeuroImage. Clinical
|July 11, 2024
概括
初级渐进性失言症 (PPA) 变体显示语音语言网络受损. 前中旋 (aMTG) 连接性崩在所有PPA类型中都是常见的,而logopenic PPA表现出更广泛的网络中断.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 认知科学 认知科学
背景情况:
- 初级渐进性失言症 (PPA) 包含不同的变体 (语音,非流利,语义),具有独特的语音语言缺陷.
- 在PPA中,语音语言网络中的相互作用及其与其他大脑网络的相互作用仍然不完全理解.
研究的目的:
- 调查左侧语音语言网络中的功能连接中断,以及在PPA变体中与其他主要大脑网络之间的功能连接.
- 为了识别PPA中共享和变种特定的连接性改变.
主要方法:
- 使用多变量线性回归模型进行功能连接性分析.
- 123名PPA患者 (55名lvPPA,44名nfvPPA,24名svPPA) 和60名健康对照患者的连接模式的比较.
- 检查语音语言网络 (Broca,Wernicke,aMTG,SMA,PT,PO) 和其他网络 (视觉协会,背部注意力,前对面注意力,DMN) 中的区域.
主要成果:
- 在所有PPA变体中观察到减少的前部中关节 (aMTG) - 布罗卡连接性,在logoopenic (lvPPA) 和非流动 (nfvPPA) 中显著.
- 变种特定的变化包括nfvPPA中的Wernicke-Broca连接性损失,lvPPA中的Wernicke-PT连接性损失,以及语义PPA (svPPA) 中MTG-PT连接性增加.
- 在各个变体中,注意到MTG默认模式网络 (DMN) 的减少和MTG背部注意连接的增加,lvPPA显示了最广泛的中断.
结论:
- 前中旋 (aMTG) 连接的破坏是所有初级渐进性失言症 (PPA) 变体的核心特征.
- 与其他变种相比,Logopenic PPA (lvPPA) 显示出更广泛的功能连接中断,涉及多个大脑网络.
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