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金属纳米复合材料对大肠杆菌的抗菌作用

Shaobo Guo¹, Xu Liu², Huihui Chen³

¹Shaanxi Key Laboratory of Catalysis, School of Chemical & Environment Science, Shaanxi University of Technology, Hanzhong, Shaanxi 723000, PR China; State Key Laboratory of Qinba Bio-Resource and Ecological Environment, Shaanxi University of Technology, Hanzhong, Shaanxi 723000, PR China.

Journal of hazardous materials

|July 11, 2024

概括

银纳米复合材料 (NA) 显示抗菌潜力,但聚合和有毒. 这项研究开发了一种ZnFe2O4@Cu-ZIF-8@Ag (FUA) 纳米复合物,具有高抗菌活性对抗大肠杆菌,并降低了细胞毒性.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
生物医学工程生物医学工程

背景情况:

银纳米复合材料 (NAs) 具有抗菌性质,但患有聚合和高细胞毒性.
纳米酸的抗菌机制和减轻其毒性的策略仍然不清楚.
开发有效和安全的抗菌纳米材料对于对抗感染至关重要.

研究的目的:

为了合成一个新的核心外结构ZnFe2O4@Cu-ZIF-8@Ag (FUA) 纳米复合材料.
为了评估FUA纳米复合物的抗菌活性和细胞毒性.
为了阐明FUA纳米复合材料的抗菌机制.

主要方法:

核心外结构的FUA纳米复合材料使用ZnFe2O4,Cu-ZIF-8和Ag进行了合成.
对大肠杆菌 (E. coli) 和抗四环素耐药的大肠杆菌 (T-E. coli) 进行了抗菌活性测试.
评估了细胞毒性,并研究了涉及离子释放和反应性氧物种 (ROS) 生成的抗菌机制.

主要成果:

在20分钟内,FUA纳米复合材料在100微克/毫升的剂量下达到99.99%的对大肠杆菌和大肠杆菌的抗菌率.
抗菌作用归因于Cu2+,Zn2+和Ag+离子的协同释放,这些离子产生基基 (•OH).
与传统的NA相比,FUA显示细胞毒性显著降低.

结论:

在FUA纳米复合物表现出强大的抗菌活性对大肠杆菌和T-E. coli,低细胞毒性.
抗菌机制涉及协同离子释放和ROS生成,导致细菌细胞壁损伤.
这项研究为开发先进的基于银的纳米复合材料,用于对抗耐药细菌提供了一个有前途的平台.

关键词:

具有抗菌活性,具有抗菌活性.埃舍里希亚大肠杆菌 (Escherichia coli) 是一个大肠杆菌.金属离子是金属离子.纳米复合材料的使用方法脂二层是一种脂二层.

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