和内分泌干扰:对人类健康的关注?
Nicolas Chevalier1, Pauline Guillou2, Catherine Viguié3
1Université Côte d'Azur, CHU, INSERM U1065, Nice, France.
Environment international
|July 11, 2024
概括
会破坏甲状腺激素系统,特别是在治疗剂量时,可能会影响神经发育. 由于其广泛的工业和医疗用途,这种新出现的污染物需要注意.
科学领域:
- 内分泌学 在内分泌学.
- 神经科学是一个神经科学.
- 环境健康 环境健康
背景情况:
- 是治疗精神疾病的关键药物,在工业中广泛使用.
- 人们越来越担心的内分泌干扰潜力,特别是它对甲状腺激素系统的影响.
- 甲状腺激素对于神经发育过程至关重要.
研究的目的:
- 对对内分泌干扰作用的现有数据进行审查,重点关注甲状腺激素系统.
- 评估在关键发育时期暴露后对神经发育的影响.
- 评估是否符合甲状腺激素系统破坏者的标准.
主要方法:
- 从PubMed和Scopus数据库中对已发表的研究进行系统审查.
- 包括人体和动物研究,检查暴露于非致病剂量的后的健康终点.
- 专注于研究发展性暴露的神经效应的研究.
主要成果:
- 暴露,特别是在治疗剂量时,与世界卫生组织对甲状腺激素系统破坏者的定义一致.
- 动物研究表明,会影响神经发育,可能是通过甲状腺激素的干扰.
- 非甲状腺机制也可能导致观察到的神经效应.
结论:
- 作为甲状腺激素系统破坏者,对神经发育有潜在的影响.
- 越来越多的在环境中存在,需要进一步研究其对甲状腺和发育神经系统的影响.
- 需要进一步的研究来阐明神经效应的所有作用模式.
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