评估应急皮肤消毒方案,以应对酸性攻击 (玻璃化) 的情况
H Matar1, P R Vuddanda2, R P Chilcott2
1Research Centre for Topical Drug Delivery and Toxicology, University of Hertfordshire, Hatfield AL10 9AB, UK..
概括
用缩的硫酸紧急清除皮肤污染,在30秒后是无效的. 湿脱污染是最有效的,但酸性攻击的身体损伤几乎立即发生,没有实际的治疗窗口.
科学领域:
- 紧急医疗 紧急医疗
- 皮肤病学 皮肤病学
- 毒理学 毒理学 毒理学
背景情况:
- 酸性攻击 (玻璃化) 会造成严重的终身损伤,需要有效的紧急护理.
- 快速消毒对于最大限度地减少化学烧伤造成的组织损伤至关重要.
研究的目的:
- 评估紧急皮肤脱污方法与缩硫酸 (H2SO4) 相比.
- 为了确定皮肤暴露后净化有效时间窗口.
主要方法:
- 使用猪皮的体外扩散细胞系统.
- 测试了四种除污方法 (干,湿,组合,棉布).
- 在暴露后的10秒,30秒,8分钟和30分钟启动了协议.
主要成果:
- 皮肤组织完整性损失早在暴露后10秒就被观察到.
- 除污染效率随着时间的推移呈指数级下降.
- 湿脱污染是最有效的,但没有一种方法在30岁后起作用.
- 完整的酸中和发生在90s灌后.
结论:
- 通过皮肤接触缩的硫酸会导致几乎瞬间的身体损伤.
- 暴露后有效的酸性去污染没有实际的时间窗口.
- 立即灌是至关重要的,但可能无法防止最初的组织损伤.
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