与纤维发酵和宿主健康相关的非SCFA微生物代谢物
Erica T Grant1, Hélène De Franco2, Mahesh S Desai1
1Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Trends in endocrinology and metabolism: TEM
|July 11, 2024
概括
食纤维有益于肠道微生物群,产生短链脂肪酸 (SCFA). 除了SCFA外,其他微生物代谢物,如二次胆酸,对宿主健康有显著影响,需要个性化的食纤维建议.
科学领域:
- 微生物组研究的研究.
- 代谢学 代谢学 代谢学
- 宿主-微生物相互作用
背景情况:
- 肠道微生物的食纤维发酵产生有益的短链脂肪酸 (SCFA).
- 个人对纤维补充剂的反应各不相同,这表明其他微生物代谢物的影响.
- 了解这些多样化的代谢物对于优化健康益处至关重要.
研究的目的:
- 从食纤维干预中审查超越SCFA的微生物代谢物的健康影响.
- 探索二次胆汁酸,芳香氨基酸衍生物,神经递质和B族维生素的作用.
- 讨论由母亲饮食和农业实践引起的代谢变化.
主要方法:
- 对食纤维干预研究的文献综述.
- 专注于除SCFA外的微生物代谢物.
- 分析了检查母亲食纤维和农业影响的研究.
主要成果:
- 微生物代谢物,包括二次胆汁酸和芳香氨基酸衍生物,显著影响宿主健康.
- 对食纤维的个性化反应与更广泛的微生物代谢产物有关.
- 改变母亲的饮食和农业实践可以改变微生物的新陈代谢.
结论:
- 优化食纤维的好处需要评估多种微生物代谢物.
- 考虑到个体微生物组的功能,个性化的建议是必不可少的.
- 对代谢变化的进一步研究是有必要的.
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