基于纳米悬浮的Repaglinide快速溶解的膜用于溶解增强
Hamsa Yaseen Ghadhban1, Kawther Khalid Ahmed2,3
1Al-Karkh Health Department, MOH, Ibn Al-Bitar Center for Cardiac Surgery, Baghdad, Iraq.
AAPS PharmSciTech
|July 11, 2024
概括
在口腔快溶膜中的Repaglinide (RPG) 纳米悬浮显著增强了药物的溶解和透. 基于Soluplus®的纳米粒子实现了最佳颗粒大小,与纯药物相比,改善了RPG输送.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 纳米技术纳米技术
背景情况:
- 药物溶解性和溶解是制药配方开发中的关键挑战.
- 雷帕格林 (RPG) 需要增强的输送策略,以提高治疗疗效.
研究的目的:
- 为了制定和评估repaglinide (RPG) 基于纳米悬浮的口腔快溶膜 (BDFs) 以提高溶解.
- 研究各种水友性聚合物对RPG纳米悬浮特性和性能的影响.
主要方法:
- 通过使用Soluplus®,PVA,PVP,Poloxamers和HPMC等聚合物通过抗溶剂沉制备的RPG纳米悬浮.
- 使用溶剂造将纳米悬浮纳入BDF.
- 特性包括颗粒大小,PDI,SEM和FTIR.
- 进行了体外溶解和体外透研究.
主要成果:
- 基于Soluplus®的纳米悬浮体表现出最佳的粒子大小 (82.6 nm) 和球形形态.
- 纳米悬浮显示在30分钟内完全释放RPG,而纯RPG的释放率为60%.
- 最佳的BDF在10分钟内证明了28秒的分解时间和97.3%的RPG释放率.
- 活体透研究显示,使用纳米悬浮膜显著改善RPG流量 (0.00275 mg/cm2/min),而不是纯RPG (0.001058 mg/cm2/min).
结论:
- 使用Soluplus®的RPG纳米悬浮配方有效增强药物溶解和口腔透.
- 口快速溶解薄膜为提供RPG纳米悬浮提供了一个可行的平台.
- 与纯RPG相比,开发的配方表现出优越的性能,为改善药物输送提供了一个有前途的方法.
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