代谢功能障碍相关的脂肪性肝病与尿病风险之间的关联:更新的系统性审查和元分析
Alessandro Mantovani1, Riccardo Morandin1, Veronica Fiorio1
1Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Verona, Verona, Italy.
Internal and emergency medicine
|July 11, 2024
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 与患结石 (结石) 的风险更高有关. 风险随着MASLD的严重程度而增加,但与新石头开发的联系需要进一步调查.
科学领域:
- 肝病学和病学 肝病学和病学
- 代谢疾病 代谢疾病
- 流行病学 流行病学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的健康问题.
- 流行病学证据表明,MASLD和尿病之间存在潜在的联系.
- 这种关联的确切性质和强度,特别是关于MASLD的严重程度,仍然不清楚.
研究的目的:
- 量化MASLD与流行性和发病性尿病的风险之间的关联.
- 为了调查尿病的风险是否随着MASLD的严重程度而变化.
- 通过全面的元分析来综合当前的证据.
主要方法:
- 对观察性研究进行了系统的元分析.
- 在PubMed,Scopus和Web of Science进行了搜索,截至2024年3月31日.
- 来自7项横截面和1项前性队列研究的数据涉及248,936名成年人,并使用随机效应建模分析了这些数据.
主要成果:
- 马斯尔德与患有流行的尿病的风险增加显著相关 (OR1.87,95% CI 1.34-2.60).
- 在MASLD严重程度和尿病之间观察到一种积极的,分级的关联.
- 预期队列数据没有显示MASLD是发生性尿病的危险因素 (HR 1.08,95% CI 0.90-1.30),尽管在男性中注意到了联系.
结论:
- 这一元分析证实了MASLD与尿病存在的显著关联.
- MASLD的严重程度似乎与现有的结石的风险增加有关.
- 需要进一步的研究来确定MASLD是否会增加患新结石的风险.
相关概念视频
01:24Overview of Lipid Metabolism
1.3K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.3K
01:26Diseases of the Liver and Gallbladder
507
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
507
01:24Chronic Pancreatitis I: Introduction
86
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
86