乳酸盐通过H3K18乳化而不是H3K27乙化来调节异位基因组激活,而不是通过H3K27乳化

Yanhua Zhao1, Meiting Zhang1, Xingwei Huang1

  • 1Department of Histology and Embryology, Harbin Medical University, Harbin, 150081, China.

概括

乳酸对小鼠早期胚胎发育至关重要,防止细胞循环停止. 它的缺失会通过改变基因激素乳化 (H3K18la) 来损害关键的发育过渡,这是对基因激活至关重要的表观遗传修饰.

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