阿斯特拉加卢斯蒙霍利克斯Bunge提取物通过促进PLCB2抑制结肠上皮细胞热致死来改善性结肠炎
Jie Shen1, Yibin Zhao1, Wei Cui1
1Department of Colorectal Surgery, Ningbo Medical Center Lihuili Hospital (Affiliated Lihuili Hospital of Ningbo University), China.
Journal of ethnopharmacology
|July 11, 2024
概括
阿斯特拉加勒斯蒙霍利克斯Bunge提取物通过降低炎症和抑制热致死,有效治疗性结肠炎 (UC). 这种传统的草药通过增强结肠细胞中的脂酶C-β 2 (PLCB2) 表达来促进愈合.
科学领域:
- 药理学 药理学是指药理学的学科.
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 阿斯特拉加勒斯蒙霍利克斯Bunge (AM) 提取物传统上用于其抗炎,抗病毒,抗氧化和免疫调节的特性.
- 它在治疗各种疾病,包括心血管,神经系统疾病和癌症方面的潜力得到了认可.
研究的目的:
- 调查阿斯特拉加卢斯蒙霍利克斯邦格提取物改善性结肠炎 (UC) 的药理机制.
- 探索 AM 提取物治疗后UC改善所涉及的生物过程.
主要方法:
- 使用德克斯硫酸 (DSS) 诱导的UC小鼠模型和结肠上皮细胞系.
- 治疗涉及AM提取物或萨拉索苏尔法皮里丁 (SASP).
- 评估的关键标志物包括脂酶C-β 2 (PLCB2) 表达,细胞增殖 (CCK-8试验) 和与热相关的炎症因子 (ELISA).
主要成果:
- 在UC小鼠中,AM提取物显著改善了疾病活性指数 (DAI),并减少了他的病理损伤.
- 治疗降低了促炎性细胞因子 (Eotaxin,GCSF,KC,MCP-1,TNF-α,IL-6) 和抑制了热致死标记物 (NLRP3,Caspase-1,GSDMD-N).
- 在体外,AM提取物逆转了DSS诱导的PLCB2减少,增强了细胞增殖,并降低了IL-1β和IL-18水平.
结论:
- 阿斯特拉加卢斯蒙霍利克斯Bunge提取物显示出治疗性结肠炎的治疗潜力.
- 提取物通过通过促进PLCB2.2.通过抑制结肠上皮细胞热致死来改善UC.
- 这项研究阐明了AM提取物在治疗UC中的有效性的一个关键机制.
相关概念视频
Drugs for Treatment of Ulcerative Colitis in IBD
134
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
134
Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents
395
The gastric mucosa produces prostaglandins E2 (PGE2) and prostacyclin (PGI2), crucial in maintaining gastric health. They exert cytoprotective effects, including increasing bicarbonate secretion, releasing protective mucin, reducing gastric acid output, and preventing harmful vasoconstriction. These effects are mediated through various receptors, such as EP1, EP2, EP3, and EP4.
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
395
Drugs for Treatment of Constipation-Predominant IBS
154
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
154
Inflammatory Bowel Disease I: Ulcerative Colitis
160
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
160
Inflammatory Bowel Disease V: Surgical Management
139
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
139
Peptic Ulcer Disease IV: Management
85
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
85


