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Updated: Jun 21, 2025

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
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Published on: May 6, 2019

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无意义的CD247突变显示T细胞受体表达和功能的主导负特征

Alejandro C Briones1, Rebeca F Megino1, Ana V Marin1

  • 1Department of Immunology, Ophthalmology and ENT, Complutense University School of Medicine and 12 de Octubre Health Research Institute (imas12), Madrid, Spain.

The Journal of allergy and clinical immunology
|July 11, 2024
PubMed
概括

在CD247中发生异构的无意义突变,影响ITAM,损害T细胞受体 (TCR) 组合和信号传递. 这些变异可能对TCR表达产生主导负面影响,可能与免疫缺陷有关.

关键词:
CD247 是一个CD247 CD247 是一个CD247在CD3中,CD3是最重要的.在ITAMITAM ITAM 在ITAM ITAM 在ITAM在TCR中,可以使用TCR.在TCR ζ ζ ζ ζ ζ自体免疫性是一种自身免疫性.免疫缺陷是一种免疫缺陷.

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