短效二甲烯雷米马佐拉姆与常见的外科手术期间药物不兼容
Pascal Hofmann1,2, Lena Bachmann1, Pia Brümmer1
1University Hospital Tübingen, Department of Anaesthesiology and Intensive Care Medicine, Tübingen, Germany.
BMC anesthesiology
|July 11, 2024
概括
雷米马佐拉姆是一种新的麻醉剂,它与17种药物呈现沉,包括安培西林/苏尔巴克坦和富罗塞米德. 确保安全的药物管理需要为雷米马拉姆提供单独的药物线,并仔细考虑药物兼容性.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
- 临床药房 临床药房
背景情况:
- 雷米马佐拉姆是一种用于麻醉和手术镇静的新型二胺.
- 以前的报道表明,与特定的静脉注射液体 (如林格的乳酸盐) 的物理不相容.
- 雷米马佐拉姆与许多常用药物的兼容性在很大程度上仍未得到研究.
研究的目的:
- 系统地评估雷米马佐拉姆与各种药物和静脉注射液体的物理兼容性.
- 通过模拟的Y位处方,通过与雷米马佐拉姆同时服用时沉的特定药物.
- 提供基于证据的推,以确保安全的雷米马佐拉姆的使用方案.
主要方法:
- 测试了65种药物和静脉注射液体,以检测它们是否与雷米马佐拉姆沉.
- 模拟的Y位处方涉及混合相同的体积和观察60分钟的降水情况.
- 混合前后由两名独立调查人员进行视觉检查和pH值测量.
主要成果:
- 在测试的药物/液体中,有17种 (26.15%) 药物/液体表现出可见的remimazolam沉.
- 没有观察到与47种 (72.31%) 药物的相互作用;由于其本身的度,无法评估醇.
- 同时服用药物的基线pH值较为基本时,沉风险增加;pH值低于5时没有发生相互作用.
结论:
- 雷米马佐拉姆与大量药物不兼容,包括安皮西林/苏尔巴克坦,葡萄糖酸,富洛塞米德,肝素,胰岛素和片.
- 安全的施用需要专门的静脉注射线用于雷米马佐拉姆,并仔细选择兼容的基线输液.
- 应考虑采用替代方法,同时与雷米马佐拉姆服用玻尿酸药物,以预防不良事件.
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