饮食模式和肝细胞癌风险:对队列和病例对照研究的系统审查和元分析
Wenxi Shu1, Ling Liu2,3, Jiaojiao Jiang1
1Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Nutrition & metabolism
|July 11, 2024
概括
富含蔬菜和全谷物的健康饮食模式与肝癌风险降低有关. 相反,炎症性饮食会增加HCC的风险,这凸显了饮食在预防癌症方面的重要性.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 营养科学 营养科学
- 在瘤学瘤学.
背景情况:
- 肝细胞癌 (HCC) 是一个重大的全球健康挑战,发病率和死亡率很高.
- 流行病学研究表明饮食和HCC风险之间存在联系,但缺乏共识.
研究的目的:
- 进行一项元分析,综合有关饮食模式与HCC风险之间的关联的文献.
- 为了提供一个全面的分析,不同的饮食如何影响患肝癌的可能性.
主要方法:
- 在PubMed,Embase和Cochrane图书馆进行系统的文献搜索,截至2023年8月.
- 使用纽卡斯尔-太华尺度和随机效应模型的元分析进行质量评估.
- 计算危险比率 (HRs) 和95%置信区间 (CI) 以量化风险.
主要成果:
- 对13项研究的分析表明,坚持健康饮食模式,如健康饮食指数 (HEI),DASH和地中海饮食,可以降低HCC风险 (HRs <1).
- 促炎症的饮食模式与HCC风险增加有关 (HR = 2.21).
- 通过后部分析确定的一种基于蔬菜的饮食模式也显示出与HCC风险的负相关性 (HR = 0.63).
结论:
- 饮食模式和肝细胞癌 (HCC) 风险之间存在显著的关联.
- 富含蔬菜,全谷物,豆类和坚果的健康饮食,低含红色和加工肉类的健康饮食,可以预防HCC.
- 炎症性饮食模式与患肝癌的风险增加有关.
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