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结合性巨诱导的针对尤文肉瘤的先天免疫疗法:同时转动"两个钥匙"

Wen Luo1,2, Hai Hoang3, Katherine E Miller4,5

  • 1Department of Pediatrics, New York Medical College, 15 Dana Road, Valhalla, NY, 10595, USA. Wen_Luo@nymc.edu.

Journal of experimental & clinical cancer research : CR
|July 11, 2024
PubMed
概括

将CD47阻断 (magrolimab) 与多克索鲁比化疗相结合,可以重新激活尤文肉瘤 (ES) 细胞的巨细胞化. 这种双重方法有效地减少了瘤负担,转移,并在临床前模型中改善了存活率.

关键词:
在CD47封锁中.化疗 化疗是一种化学疗法.尤文肉瘤 (Ewing Sarcoma) 是一种癌症.巨细胞是一个巨细胞.

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Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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