化学放射治疗与放射治疗在高风险的唾液腺癌中
1Department of Stomatology, Affiliated Hospital of Shaoxing University, Shaoxing, 312000, China.
World journal of surgical oncology
|July 11, 2024
概括
化疗放射治疗 (CRT) 对具有高级阶段,高等级和多个阳性淋巴结的高风险唾液腺癌 (SGC) 患者提供生存益处. 对于其他高风险的SGC病例,CRT对单独放射治疗没有显著的优势.
科学领域:
- 在瘤学瘤学.
- 癌症研究 癌症研究
- 头部和部癌症 头部和部癌症
背景情况:
- 唾液腺癌 (SGC) 是一种罕见的恶性瘤.
- 高危的SGC需要积极的辅助治疗策略.
- 化学放射治疗 (CRT) 与放射治疗 (RT) 在切除高风险SGC中的作用仍在争论中.
研究的目的:
- 评估CRT与RT在切除高风险SGC中的生存益处.
- 为了确定高风险变量的数量是否影响治疗疗效.
- 确定可能受益于辅助CRT的特定患者亚组.
主要方法:
- 对152名切除高风险SGC患者的回顾性分析.
- 患者被分为CRT和RT组.
- 倾向性得分匹配和多变量Cox模型用于评估局部区域控制 (LRC) 和整体存活率 (OS).
主要成果:
- 总的来说,CRT与RT相比没有显著改善LRC或OS.
- 在T3/4阶段,高度瘤和≥5个阳性淋巴结的患者中,观察到CRT显著的生存优势 (复发风险减少15%).
- 在其他高危子组中,没有发现CRT对生存的额外益处.
结论:
- 用RT (CRT) 进行辅助化疗可能对特定高风险SGC患者有益.
- 考虑CRT用于切除T3/4阶段,高等级和≥5阳性淋巴结的高风险SGC.
- 对于其他高风险SGC患者的个人资料,单独RT可能就足够了.
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