有机酸乙阻燃化学物质和孕期孕产妇抑郁症
Ixel Hernandez-Castro1, Sandrah P Eckel2, Caitlin G Howe3
1Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Department of Epidemiology and Population Health, Stanford Medicine, Stanford, CA, USA.
怀孕期间暴露于有机酸 (OPEs) 与增加母亲抑郁症状有关. 较高水平的DPHP和BDCIPP代谢物与更高的产前抑郁症风险有关.
科学领域:
- 环境健康 环境健康
- 生殖健康 生殖健康
- 神经科学是一个神经科学.
背景情况:
- 怀孕是母亲心理健康的脆弱时期,抑郁症是导致疾病的重要因素.
- 有机酸 (OPE) 是一种常见的环境化学物质,具有潜在的神经毒性作用.
- 对OPE暴露对产前抑郁症的影响尚不清楚.
研究的目的:
- 调查第三季度OPE代谢物度与怀孕期间母亲抑郁症状之间的关联.
- 探索OPE混合物对产前抑郁风险的综合影响.
主要方法:
- 对MADRES队列中422名孕妇参与者的尿样进行分析.
- 在第三季度尿液中测量了9种OPE代谢物.
- 使用CES-D尺度 (得分≥16) 进行可能抑郁症的分类.
- 修改后的Log-Poisson回归和贝叶斯内核机器回归 (BKMR) 用于评估关联.
主要成果:
- 对DPHP和BDCIPP代谢物的高暴露与67%和47%的抑郁症状风险增加有关.
- 对于其他单独的OPE代谢产物,没有发现显著的关联.
- 混合物分析显示,OPE代谢物混合物与产前抑郁症之间存在积极的线性关联,主要是由DPHP驱动的.
结论:
- 这项研究提供了新的证据,将常见的OPE代谢物与怀孕期间母亲的抑郁症状联系起来.
- 这些发现突显了OPE暴露在围产期心理健康中的潜在作用.
- 结果可能会为旨在减少产前抑郁症的干预措施提供信息.
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