审查加拿大卫生部在基于人体生物监测的风险评估方面的进展,以及前进的道路
Devika Poddalgoda1, Kristin Macey1, Natasha Chander1
1Health Canada, 269 Laurier Ave (W), Ottawa, ON K1A 0K9, Canada.
Toxicology letters
|July 11, 2024
概括
加拿大卫生部根据加拿大环境保护法 (CEPA) 使用人类生物监测 (HBM) 数据对化学品进行风险评估 (RA). 未来的方法将纳入弱势群体和新的生物标志物,以加强公共卫生风险评估.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 公共卫生政策 公共卫生政策
背景情况:
- 自2006年以来,加拿大卫生部的化学品管理计划 (CMP) 已经评估了数千种优先物质.
- 人类生物监测 (HBM) 数据已成为300多种物质的风险评估 (RA) 的组成部分.
- 生物监测等效 (BE) 已开发用于解释HBM数据用于监管目的.
研究的目的:
- 概述加拿大卫生部在利用HBM数据进行人类健康风险评估方面的进展.
- 讨论基于HBM的RA方法的开发和应用,以提高监管效率.
- 根据最近的CEPA修正案,探索基于HBM的RA的未来方向.
主要方法:
- 为加拿大普通人口开发基于HBM的定性和定量RA方法.
- 导出生物监测等价值 (BE) 来解释HBM数据.
- 进行化学混合物的累积风险评估,使用HBM数据作为暴露度.
主要成果:
- 已使用HBM数据评估了300多种优先物质.
- 基于HBM的RA提高了查潜在健康风险的效率.
- 对化学混合物进行了累积风险评估.
结论:
- 加拿大卫生部在应用HBM数据以加强风险评估方面取得了重大进展.
- 最近的CEPA修正案要求包括弱势群体和累积效应.
- 未来的战略包括探索先进的生物标志物 (效果,非传统) 以满足不断变化的监管要求.
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