冠状病毒疾病2019疫苗接种后的血栓栓塞在心房动/动中:一个自我控制的病例系列研究研究
You-Jung Choi1,2, Jaehyun Lim2, Sungho Bea3,4
1Division of Cardiology, Department of Internal Medicine, Korea University Guro Hospital and Korea University College of Medicine, Seoul, Republic of Korea.
European heart journal
|July 12, 2024
概括
对于心房动/动 (AF/AFL) 患者来说,COVID-19 疫苗接种通常是安全的,没有表现出血栓栓塞事件的风险增加. 然而,未接种疫苗的患者需要仔细评估,因为接种疫苗后风险较高.
科学领域:
- 心脏病学 心脏病学
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- 由于有血栓栓塞事件报告,人们对心房动/动 (AF/AFL) 患者的COVID-19疫苗安全存在担忧.
- 在AF/AFL人群中评估与疫苗相关的血栓栓塞风险至关重要.
研究的目的:
- 评估在患有AF/AFL的个体接种COVID-19疫苗后发生血栓栓塞事件的风险.
- 在AF/AFL群体中确定特定的患者亚组,这些患者可能面临改变的风险.
主要方法:
- 采用了经过修改的自我控制的案例系列研究设计.
- 利用了韩国的综合性全国链接的健康数据库.
- 包括12岁以上的个体,分析疫苗接种后21天内发生的血栓栓塞事件.
主要成果:
- 在AF/AFL患者接种疫苗后发生的血栓栓塞事件的总发病率比率 (IRR) 为0.93 (95% CI 0.77-1.12).
- 根据性别,年龄或疫苗类型,没有观察到显著的风险差异.
- 没有接受抗凝剂治疗的患者显示IRR显著更高,为1.88 (95% CI 1.39-2.54).
结论:
- 在患有AF/AFL的患者中,COVID-19疫苗接种似乎没有提高血栓栓塞事件的整体风险.
- 对于不接受口服抗凝药的AF/AFL患者来说,个体风险评估至关重要.
- 这些患者需要仔细考虑,因为疫苗接种后血栓栓塞事件的风险增加.
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