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Updated: Jun 21, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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条件 PROTAC:调节向蛋白质降解的最新策略

Junhyeong Yim1,2, Junyoung Park1,3, Gabin Kim4

  • 1Department of Chemistry, Kangwon National University, Chuncheon, 24341, Republic of Korea.

ChemMedChem
|July 12, 2024
PubMed
概括

向蛋白解酶的仿真体 (PROTACs) 通过无素-蛋白酶体系统 (UPS) 提供有针对性的蛋白质降解. 本综述探讨了空间时间控制的化学策略,以提高PROTAC的疗效并最大限度地减少副作用.

关键词:
这就是PROTAC.空间的 PROTAC 空间的 PROTAC时间空间 PROTAC 时间空间 PROTAC有针对性的蛋白质降解 (TPD)时间 PROTAC 时间 PROTAC

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