在瑞典南部,乳病发病率正在下降
Jesper Lexner1,2, Spencer Clarkson3, Klas Sjöberg1,2
1Department of Gastroenterology and Nutrition, Skåne University Hospital, Malmö, Sweden.
Scandinavian journal of gastroenterology
|July 12, 2024
概括
在瑞典南部,乳病发病率正在下降,特别是在儿童和妇女中. 这一趋势表明环境因素可能在乳病 (CD) 的发展中发挥作用.
科学领域:
- 胃肠病学 胃肠病学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 在20世纪末和21世纪初,乳病 (CD) 的发病率显著增加.
- 最近的数据表明,在患病率高的国家,疾病发病率趋于平稳.
- 调查瑞典南部目前的CD趋势至关重要.
研究的目的:
- 分析目前在瑞典南部的乳病 (CD) 的时间和地理趋势.
- 为了确定不同年龄组和性别的CD发病率的变化.
- 探索CD诊断中的区域差异.
主要方法:
- 在瑞典南部斯卡内 (2010-2022) 进行了活检或血清学诊断的CD病例的回顾性分析.
- 利用人口登记册识别患者地址进行趋势分析.
- 计算了年龄标准化的发病率,并分析了随时间的变化趋势.
主要成果:
- 确定了3218名乳病患者,其中52.2%为儿童.
- 观察到CD的发病率下降 (-0.75例/10^5每年).
- 在18岁以下的女孩中,发病率显著下降,而在男性中发现了小幅变化;最常见的发病年龄为3-9岁. 在小城镇中,CD的发病率更高.
结论:
- 在瑞典南部,乳病 (CD) 发病率正在下降,特别是在儿童和妇女中.
- 诊断CD的最高频率发生在3-9岁儿童中.
- 区域差异和小城镇更高的发病率表明,环境因素在CD病因学中很重要.
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