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怀孕期间的COVID-19感染和早期和晚期自发流产的风险:一个匹配的病例控制基于人口的研究

Rawan Karawani^1,2,3, Oshri Barel^1,2, Liat Lev-Shalem³

¹Department of Obstetrics and Gynecology, Assuta Ashdod University Hospital, Ashdod, Israel.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

|July 12, 2024

概括

在怀孕早期的COVID-19感染显著增加了自发流产的风险. 这一发现突出了怀孕个体与2019年冠状病毒病相关的潜在风险.

科学领域:

产科和妇科产科和妇科
传染性疾病传染性疾病
流行病学流行病学

背景情况:

COVID-19对怀孕结果的影响仍然是研究的关键领域.
怀孕早期是胎儿发育的脆弱时期.

研究的目的:

评估COVID-19在第一季度对第一和第二季度流产率的影响.
评估COVID-19症状严重程度与妊娠结果 (包括死产) 之间的相关性.

主要方法:

一个回顾性,基于人群的,匹配的病例控制研究.
一个大型以色列医疗机构的电子病历数据 (2020年 vs. 2019年).
将COVID-19阳性孕妇的怀孕结果与与年龄和妊娠周相匹配的流行前对照组进行比较.

主要成果:

与对照组 (4.7%) 相比,在COVID-19阳性患者 (6.3%) 中观察到明显更高的自发流产率.
流产率的增加在第一季度最明显 (5.4%对3.8%).
在COVID-19症状严重程度和流产风险之间没有发现任何关联.

结论:

在怀孕早期的COVID-19诊断与自发流产率的增加有关.
这些发现强调了保护孕妇免受SARS-CoV-2感染的重要性,特别是在头三个月.

关键词:

这是一个COVID-19感染.在SARS-CoV-2中.流产流产流产流产怀孕怀孕怀孕怀孕怀孕三个月的三个月.

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