针对BCG不响应的高风险非肌肉侵入性膀癌的新型肠道药物
Anastasios D Asimakopoulos1, Maxim Kochergin2, Gaia Colalillo1
1Urology Unit, Fondazione PTV Policlinico Tor Vergata, Rome, Italy.
Bladder cancer (Amsterdam, Netherlands)
|July 12, 2024
概括
新的静脉内疗法对BCG不响应的膀癌有前途. 纳多法基因 (Nadofaragene firadenovec) 和其他药物为高风险的非肌肉侵入性膀癌 (NMIBC) 提供了新的救援治疗选择.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 高风险的非肌肉侵入性膀癌 (NMIBC) 缺乏标准的二线治疗方法,除了瓦卢比辛和潘布罗利祖马布.
- Calmette-Guérin (BCG) 不响应的NMIBC对有效的救援疗法的显著未满足的临床需求.
研究的目的:
- 系统地审查用于救援治疗BCG不响应的NMIBC的新型静脉治疗剂.
- 评估这些新兴治疗方法的疗效,耐用性,生存结果和毒性概况.
主要方法:
- 在PubMed,EMBASE和Web of Science数据库中进行了全面的文献搜索.
- 疗效终点包括完全响应率 (CR),CR的持久性,整体存活率,无复发存活率和癌症特异性存活率.
- 我们搜索了clinicaltrials.gov以确定正在进行的调查.
主要成果:
- 内基因疗法,特别是纳多法拉基因 (nadofaragene firadenovec),显示出对高风险NMIBC的显著进展的潜力.
- 使用N-803/BCG的组合疗法和创新的药物输送系统也产生了有希望的结果.
- 包括14项研究,突出了该领域的积极发展.
结论:
- 新的静脉注射药物和对BCG不响应的NMIBC的治疗策略预计将很快可用.
- 泌尿科医生需要根据个体患者的个人资料选择最佳药物,同时考虑安全性,疗效和成本效益.
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