遗传性胃癌与遗传性乳腺癌和卵巢癌有关
Takuma Hayashi1, Kenji Sano2, Mako Okada1
1Cancer Medicine, National Hospital Organization Kyoto Medical Center, Kyoto 612-8555, Japan.
World journal of oncology
|July 12, 2024
概括
杆菌感染和BRCA1/2病原体变异在遗传性乳腺和卵巢癌家族中协同增加胃癌风险. PARP 抑制剂可能提供一种潜在的治疗策略.
科学领域:
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
- 微生物学 微生物学
背景情况:
- 杆菌感染是胃癌 (GC) 的已知危险因素.
- BRCA1/2致病变体 (PVs) 与遗传性乳腺和卵巢癌 (HBOC) 综合征有关,也与GC发展有关.
- 连接H. pylori,BRCA1/2 PVs和GC的分子机制仍然不清楚.
研究的目的:
- 为了澄清H. pylori感染,BRCA1/2 PVs和HBOC家族中的GC发生率之间的分子联系.
- 研究H. pylori感染和BRCA1/2 PVs对GC发育的协同作用.
主要方法:
- 对接受精确癌症基因组医学的日本患者数据的回顾性审查.
- 与非HBOC家族相比,对具有生殖系 BRCA1/2 PVs 的 HBOC 家庭的 GC 发生率的分析.
- 在先进的GC患者中评估BRCA1 / 2PV和在小鼠模型中野生型BRCA1 / 2表达的影响.
主要成果:
- 具有生殖系BRCA1/2PVs的HBOC家族显示,GC发病率显著更高 (2.95%与0.78%).
- 超过16%的晚期GC患者患有生殖系BRCA2PV,96.1%的H. pylori感染患者接受了癌症基因组药物治疗晚期GC.
- 野生型BRCA1/2的表达在小鼠模型中抑制了GC的发展,这表明它具有保护作用.
结论:
- H. pylori 感染和生殖线 BRCA1/2 PVs 协同增加了 GC 发展的风险.
- 针对BRCA1/2 PVs的治疗剂的研究对于预防HBOC家族中的GC至关重要.
- 聚 (ADP-ribose) 聚合酶 (PARP) 抑制剂在患有生殖 BRCA1/2 PVs 的患者中显示出抑制 GC 发育和进展的潜力.
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