增加维生素C摄入量与降低胰腺癌风险有关
Maria Pereira1, Matthew Cardeiro1, Lexi Frankel1
1Nova Southeastern University, Dr. Kiran C. Patel College of Allopathic Medicine, Fort Lauderdale, FL, USA.
World journal of oncology
|July 12, 2024
概括
在一项大型国家研究中,摄入维生素C与胰腺癌发病率较低有关. 这表明维生素C在胰腺癌风险中的潜在预防作用.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 胰腺癌的预后不好,五年生存率约为3%.
- 诊断往往发生在较晚的阶段,导致低生存率.
- 以前的研究表明,维生素C可能在胰腺癌的预防和治疗中发挥作用.
研究的目的:
- 调查维生素C摄入量与患胰腺癌的风险之间的关联.
- 分析有或没有维生素C摄入史的患者的胰腺癌发病率.
主要方法:
- 从2010年1月到2020年12月使用符合HIPAA的国家数据库.
- 员工使用国际疾病分类 (ICD-9和ICD-10) 代码来识别患者.
- 根据查尔森并发症指数 (CCI) 得分和年龄对应的患者,使用基平方和逻辑回归分析.
主要成果:
- 总共有83,941名接受维生素C处方的患者被确定.
- 在匹配后,每个组中有50,384名患者 (维生素C与对照组).
- 胰腺癌发病率在维生素C组为0.48%,对照组为0.88% (几率比:0.548,P<3.174 × 10-14).
- 维生素C的处方与所有年龄段和美国地区的胰腺癌患病率降低有关.
- 在对照组中,医疗保健费用更高.
结论:
- 维生素C摄入量与胰腺癌发病率降低之间存在统计学上显著的相关性.
- 建议进行进一步的研究,以探索维生素C在胰腺癌中的机制 (redox,cofactor活性).
- 建议与维生素C一起考虑生活方式风险因素,如吸烟.
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