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Updated: Jun 21, 2025

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions
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Published on: May 27, 2021

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特里弗卢诺胺/莱弗卢诺胺通过减少SCLC中DRP1的线粒体碎片化,与化疗药物产生协同作用

Tamara Mirzapoiazova1, Liz Tseng2, Bolot Mambetsariev1

  • 1Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010, USA.

iScience
|July 12, 2024
PubMed
概括

新的SCLC疗法显示出有希望的结果. 勒弗卢诺胺和特里弗卢诺胺通过影响线粒体分裂来抑制癌细胞生长. 在临床前模型中,与卡博普拉丁和卢比内克丁等化疗药物的组合显示出显著的抗瘤作用.

关键词:
癌症 癌症 癌症 癌症 癌症细胞生物学 细胞生物学分子生物学分子生物学生理学 生理学 生理学

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