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KCL TEST:一个开源启发的无症状SARS-CoV-2监测计划在一个学术机构

Joana Reis de Andrade¹, Edward Scourfield¹, Shilpa Lekhraj Peswani-Sajnani¹

¹Research Management and Innovation Directorate, KCL TEST, King's College London, London, UK.

Biology methods & protocols

|July 12, 2024

概括

KCL TEST提供了免费,可访问的SARS-CoV-2唾液PCR测试,实现了16小时的周转时间. 这项由大学主导的计划证明了定期无症状测试对社区健康和流行病准备的价值.

科学领域:

病毒学病毒学
公共卫生公共卫生
实验室诊断实验室诊断实验室诊断

背景情况:

由于COVID-19的流行,人们需要快速且易于使用的诊断测试.
无症状传播对疾病控制构成了重大挑战.
大学拥有未充分利用的公共卫生倡议资源.

研究的目的:

描述KCL TEST的建立和运作,这是一个基于大学的SARS-CoV-2无症状测试计划.
为建立类似的诊断实验室提供蓝图,特别是在资源较少的环境中.
评估社区无症状测试在控制病毒传播方面的有效性.

主要方法:

实施一个敏感的SARS-CoV-2RNA唾液PCR测试程序.
利用开源自动化和内部,非商业试剂,以实现成本效益和快速部署.
在2020年12月至2022年7月期间,执行了158,277次PCR测试.

主要成果:

从注册到结果的平均交付时间为16小时37分钟.
与国家监测数据相比,检测到的阳性率较低,对Delta变种的检测很少.
在大学社区中证明了大规模,免费无症状测试的可行性.

结论:

定期无症状的社区测试是有效的减少疫情和确保安全的环境.
学术机构可以通过敏捷和准确的测试能力在疫情准备中发挥关键作用.
在学术环境中开发的低成本,高效的诊断管道对于未来的公共卫生紧急情况至关重要.

关键词:

在 COVID-19 疫情中,诊断诊断诊断诊断诊断卫生公平性健康公平性分子测试试验分子测试这是一个开源的开源软件.全球疫情防控准备工作

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