胃腺癌中因感染引起的死亡风险:基于人口的研究
Adnan Malik1, Farman Ali2, Muhammad Imran Malik3
1Division of Gastroenterology, Mountain Vista Medical Center, Mesa, AZ, USA.
Gastroenterology research
|July 12, 2024
概括
老年胃腺癌患者,特别是没有接受化疗或手术的男性,面临更高的感染死亡风险. 对这些因素的早期干预对于改善生存结果至关重要.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 医学统计 医学统计
背景情况:
- 胃腺癌 (GAC) 是癌症死亡的一个重要原因.
- 手术后的并发症,特别是感染,会对GAC的预后和存活率产生不利影响.
- 对于GAC患者的术后并发症及其相关风险因素的了解有限.
研究的目的:
- 确定胃腺癌患者术后并发症的可修改和不可修改的风险因素.
- 分析这些风险因素对感染相关死亡率和整体存活率的影响.
- 为高风险GAC患者群体提供有针对性的干预信息.
主要方法:
- 利用监测,流行病学和最终结果 (SEER) 数据库来提取患者数据.
- 采用了统计分析,包括皮尔森的奇平方,考克斯回归,卡普兰-梅尔和二进制回归.
- 分析了59580名已确诊的胃腺癌患者的数据.
主要成果:
- 感染性死亡风险在50岁以上的患者 (HR: 3.137),没有接受化疗 (HR: 1.669) 或手术 (HR: 1.412) 的患者和未分期的患者 (HR: 1.699) 中显著增加.
- 相反,女性 (HR:0.658) 和已婚患者 (HR:0.627) 的死亡风险较低.
- 在老年患者 (OR:2.094),某些种族群体,特定瘤位置 (较小曲率,NOS) 和没有接受化疗的患者中观察到更高的感染概率 (OR:1.258).
结论:
- 老年,未婚的男性患有GAC被确定为感染相关死亡率高风险组.
- 不接受化疗或手术的患者面临更高的风险.
- 建议对这些易受伤害的GAC患者小组给予特别关注和量身定制的治疗策略,以减轻死亡率.
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