老龄化,认知衰退和体育炼的影响:动物模型的复杂性和考虑
Maria Giovanna Caruso1,2, Sarah Nicolas1,2, Paul J Lucassen3,4
1Department of Anatomy and Neuroscience, University College Cork, Ireland.
Brain plasticity (Amsterdam, Netherlands)
|July 12, 2024
概括
身体炼可以增强成人海马神经发生 (AHN),这一过程对认知至关重要,随着年龄的增长而下降. 本综述探讨了动物的不同运动类型如何对抗与年龄相关的认知衰退,并讨论了肠-大脑轴.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 运动科学 运动科学
背景情况:
- 与年龄相关的认知衰退和痴呆症给医疗保健带来了重大挑战.
- 预防策略至关重要,因为缺乏有效的治疗方法.
- 身体炼是大脑健康的有希望的非药物干预措施.
研究的目的:
- 在临床前动物研究中审查和比较运动范式.
- 检查运动对与年龄相关的认知衰退和成人海马神经发生 (AHN) 的影响.
- 探索肠-大脑轴在运动介导的认知效益中的作用.
主要方法:
- 在动物模型中对炼范式进行比较的审查.
- 对有关运动,衰老,认知和AHN的现有文献进行分析.
- 讨论关于肠道微生物群和肠-大脑轴的新兴研究.
主要成果:
- 运动可以增强AHN,这是认知功能的关键因素.
- 不同的运动类型对老年动物的认知表现产生不同的影响.
- 肠-大脑轴为优化炼效益提供了一个潜在的途径.
结论:
- 临床前动物研究对于了解运动诱导的认知益处至关重要.
- 优化炼方案可以为预防认知衰退的临床策略提供信息.
- 准肠-大脑轴可能会增强运动对老化大脑的积极影响.
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