父母的饮食维生素B12会导致代际增长加速,并保护后代免受致病性微型菌和细菌的侵害
Alexandra R Willis1, Winnie Zhao1, Ronesh Sukhdeo1
1Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
iScience
|July 12, 2024
概括
父母接触维生素B12可以加速后代的生长,并增强C. elegans的一代人对病原体的耐受性. 这种代际效应依赖于 metionin 生合成和 propionyl-CoA 分解途径.
科学领域:
- * 发育生物学 发育生物学
- * 微生物学 微生物学
- * 遗传学 在遗传学方面
背景情况:
- *父母环境对像C. elegans这样的模型生物的后代发育和免疫力有显著的影响.
- * 维生素B12此前已与"C. elegans"的加速发育和对细菌病原体的保护有关.
- *父母饮食对后代代际影响的机制尚未完全理解.
研究的目的:
- * 调查父母饮食中的维生素B12对*C. elegans*后代发育和免疫力的影响.
- * 阐明维生素B12介导的代际效应中涉及的分子途径.
- * 为了确定父母维生素B12是否会对特定的细菌和细菌病原体产生耐受性.
主要方法:
- * *C. elegans*暴露于补充维生素B12或维生素B12生产细菌的饮食中.
- *评估了后代的生长率,感染期间的生殖能力和生存率.
- * 基因分析重点关注 metionin 生物合成和 propionyl-CoA 分解途径.
主要成果:
- *父母的维生素B12暴露导致了一代子女的增长加速.
- *后代表现出增加的生殖能力和耐受性,以 *Nematocida parisii * 感染.
- *观察到对*Pseudomonas vranovensis*的保护,这种保护通过 metionin生物合成和propionyl-CoA通路的介导.
结论:
- *父母的微生物饮食,特别是维生素B12,可以为后代规划加速生长和增强病原体耐受性.
- * 氨酸生物合成途径对于调解这些代际效应至关重要.
- * 维生素B12从父母传给后代是一种使后代适应环境条件和病原体暴露的机制.
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