为COVID-19应用设计和实现肺器官培养物
Bing Ren1, Tryanni R Chiaravalloti2, Nadine L Belony3
1Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, FL 32611.
Bio-design and manufacturing
|July 12, 2024
概括
三维有机体培养提供了先进的体外模型,用于研究COVID-19病原和药物查. 这些复杂的模型增强了对SARS-CoV-2的理解,并加速了治疗的发展.
科学领域:
- 生物医学科学 生物医学科学
- 传染性疾病 传染性疾病
- 细胞生物学 细胞生物学
背景情况:
- 由SARS-CoV-2引起的2019年冠状病毒病 (COVID-19) 构成了全球健康威胁.
- 对于COVID-19研究和药物开发而言,急需先进的体外模型.
- 传统的二维培养和动物模型在对人类生理学进行病毒研究时存在局限性.
研究的目的:
- 审查COVID-19研究的3D有机体技术的最新进展.
- 突显有机体在理解病毒病原学的有用性.
- 讨论有机体在药物查和治疗开发中的潜力.
主要方法:
- 关于自组装和工程器官模型的当前文献的综述.
- 在研究SARS-CoV-2感染和宿主反应中分析有机物应用.
- 评估用于抗病毒药物疗效测试的有机体平台.
主要成果:
- 与2D培养相比,3D有机体培养提供了更高的细胞复杂性和更符合人类的体外环境.
- 有机物促进研究COVID-19病理学,病毒复制和宿主-病原体相互作用.
- 有机技术显示出对针对SARS-CoV-2的潜在治疗药物的高通量查的前景.
结论:
- 有机模型代表了比传统的COVID-19研究方法的重大进步.
- 这些3D体外系统是剖析病毒病原和加速开发有效治疗的宝贵工具.
- 对有机体技术的进一步开发和标准化将增强它们对传染病研究的影响.
更多相关视频
相关概念视频
01:16Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen
Oxygen therapy is a pivotal aspect of medical care, particularly for patients with respiratory ailments. Two prominent oxygen-delivering systems include the Venturi mask and the transtracheal oxygen catheter.
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
01:23Oxygen Delivering System III: Tracheostomy and T-piece
Oxygen delivery is critical in clinical care, especially for patients with respiratory disorders or those undergoing surgical procedures. Various systems, such as tracheostomy and the T-piece, deliver oxygen to the lungs, ensuring adequate arterial oxygenation.
Tracheostomy
A tracheostomy is a surgically created opening (stoma) in the anterior part of the trachea. It is used to establish a patient airway, bypass an upper airway obstruction, simplify the removal of secretions, permit long-term...
Tracheostomy
A tracheostomy is a surgically created opening (stoma) in the anterior part of the trachea. It is used to establish a patient airway, bypass an upper airway obstruction, simplify the removal of secretions, permit long-term...