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Updated: Jun 21, 2025

Quantitative and Temporal Control of Oxygen Microenvironment at the Single Islet Level
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在皮下植入的宏封装器件中的缺氧限制了密集装载小岛的生存能力和功能

Samuel A Einstein1,2, Leah V Steyn3, Bradley P Weegman1,4

  • 1Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, United States.

Frontiers in transplantation
|July 12, 2024
PubMed
概括

皮下小岛的宏封装显示设备内的氧气水平 (PO2) 较低,影响小岛的活力. 较高的小岛密度导致活力降低,这表明细胞亡是细胞损失的关键因素.

关键词:
化物-19 是一种.缺氧 缺氧是指缺氧的情况.免疫隔离 免疫隔离岛屿移植移植小岛移植磁共振光谱学 磁共振光谱学组织工程是组织工程.

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The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
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