结节再生性增生和肝移植:系统性审查
Ben E Biesterveld1, Paul M Schroder1, Mary E Hitchcock2
1Department of Transplant Surgery, University of Wisconsin, Madison, WI, United States.
Frontiers in transplantation
|July 12, 2024
概括
结节再生性增生 (NRH) 是肝脏疾病和门外高血压的罕见原因. 本综述检查了肝移植接受者的NRH,发现它发生在0.9%的病例中,并且可以在移植后发展.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 移植手术 移植手术
- 胃肠病学 胃肠病学
背景情况:
- 结节性再生性增生 (NRH) 是一种主要的肝脏疾病.
- 它可以导致非循环门高血压.
- 在现代免疫抑制方案和肝移植后的NRH方面存在有限的数据.
研究的目的:
- 在肝移植的背景下,系统地审查结节性再生性增生症 (NRH).
- 为了分析NRH作为肝移植的指示.
- 调查肝移植后发展的NRH的发生率和结果.
主要方法:
- 对NRH和肝移植的研究进行全面的文献搜索.
- 包括NRH作为移植指示的19项研究.
- 包括13项关于移植后NRH发展的研究.
主要成果:
- 肝移植接受者的0.9%具有NRH.
- 113名NRH患者接受了肝移植,通常是在失败的门性高血压治疗后进行的.
- 移植后NRH的综合发病率为2.9%,导致门高血压并发症.
结论:
- 由于NRH引起的门性高血压并发症是肝移植的罕见征兆.
- 移植后的NRH可以随时发生,有时没有明确的原因,可能需要重新移植.
- 对NRH移植后的移植和患者存活率分别为73%-78%和73%-90%.
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