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The Blood-brain Barrier00:49

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Assessment of Blood-brain Barrier Permeability by Intravenous Infusion of FITC-labeled Albumin in a Mouse Model of Neurodegenerative Disease
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通过FUS介导的BBB开口导致暂时的输液减少和炎症,而没有急性或慢性脑病变.

Sébastien Rigollet1,2, Claire Rome2, Thomas Ador3,4,5

  • 1Image Guided Therapy, Pessac, France.

Theranostics
|July 12, 2024
PubMed
概括
此摘要是机器生成的。

聚焦超声波 (FUS) 暂时打开血脑屏障 (BBB),导致脑血流 (CBF) 和血液体积分数 (BVf) 的短暂变化. 这项神经成像研究揭示了FUS诱导的BBB打开后的短期血液动力学影响和随后的神经炎症.

关键词:
关于MR的指导意见这就是为什么MRI是MRI.聚焦式超声波的使用神经炎症是一种神经炎症.二次生物效应二次生物效应

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科学领域:

  • 神经成像是一种神经成像.
  • 生物医学工程 生物医学工程
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 用MR指导的聚焦超声波 (FUS) 提供了一种非侵入性方法来打开血脑屏障 (BBB).
  • 了解BBB打开后的血液动力学变化对于优化治疗交付和患者结果至关重要.
  • 大脑血液动力学参数和神经炎症需要仔细评估临床转化.

研究的目的:

  • 评估MR引导的FUS诱导的BBB开放对大脑血液动力学的影响.
  • 在FUS应用过程中监测化水平.
  • 在BBB透后量化纵向神经炎症标志物.

主要方法:

  • 用MR指导的FUS应用于皮质或条纹体,以打开BBB.
  • 使用MRI监测大脑血流 (CBF),血液体积分数 (BVf) 和明显扩散系数 (ADC).
  • 使用被动化探测器 (PCD) 监测化,并使用国际超声诊断 (IUD) 索引进行分类.

主要成果:

  • 在所有受试者中,成功地实现了BBB打开,并且具有最小的不良空洞化.
  • 在FUS后观察到CBF (高达54%) 和BVf (高达15%) 的暂时下降,在90分钟内恢复到基线.
  • 神经炎症标志物显示星细胞招募和微质激活的短暂增加,在7天内消失.

结论:

  • 导向MR的FUS诱导的BBB打开导致中枢神经系统中暂时的血液动力学变化.
  • 这些血液动力学变化表明营养和氧气供应的短暂减少.
  • 这些发现对于完善FUS参数以确保安全有效的治疗提供至关重要.