在被诊断为1型糖尿病的青少年中,微专尿和脂质变化
Walaa Mohammedsaeed1, Dalal Nasser Binjawhar2
1Department of Clinical Laboratory Sciences, Faculty of Applied Medical Science at Taibah University, Saudi Arabia.
Heliyon
|July 12, 2024
概括
近60%的1型糖尿病 (T1DM) 青少年患有脱脂症,这是一种与小蛋白尿和心血管疾病 (CVD) 风险相关的疾病. 早期查脂质异常和功能对于管理T1DM患者至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
背景情况:
- 患有1型糖尿病 (T1DM) 的青少年面临心血管疾病 (CVD) 和脏并发症的风险增加.
- 脂质异常 (脂质失调) 在T1DM中很常见,可能会导致心血管疾病风险.
- 微专尿是损伤的早期标志物,也是心血管疾病的预测因素.
研究的目的:
- 为了确定患有T1DM的青少年脂质异常的患病率.
- 在这个人群中调查脂质不良症,微蛋白尿和心血管疾病 (CVD) 风险因素之间的关联.
- 探索基于性别的流行和关联的潜在差异.
主要方法:
- 对600名被诊断患有T1DM的青少年的数据进行了回顾性分析.
- 评估脂质特征 (总胆固醇,甘油三),小蛋白尿 (A2,A3阶段),估计的淋巴细胞过率 (eGFR) 和心血管风险因素.
- 统计分析以确定脂质水平,微专尿和其他参数之间的相关性.
主要成果:
- 脱脂症在59.7%的青少年中普遍存在.
- 在59.2%的参与者中发现了微专尿症 (A2/A3).
- 在脂质水平和微专尿之间观察到显著的相关性 (例如,TC与A2 / A3,TG与A2 / A3).
- 女性显示A2微专尿的更高患病率和轻微的eGFR下降.
- 血的无氧原体指数 (AIP),HbA1c和尿中的白蛋白与肌素比率 (UACR) 显示出强烈的正相关性.
结论:
- 患有T1DM的青少年表现出高频率的失脂症和微专尿症.
- 在这个人群中,失脂血症和微专尿明显相关,增加了心血管风险.
- 患有T1DM的女性似乎更容易患有微专尿及其相关风险.
- 对脂质异常和功能进行全面查对于管理T1DM青少年心血管风险至关重要.
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