间歇性成熟度和结直肠癌预后的相关性分析:元分析
Zhen-Jun Liu1, Xu-Wen Zhang2, Qi-Qi Liu3
1Department of Gastrointestinal Surgery, Feicheng People's Hospital, Feicheng 271600, Shandong Province, China.
World journal of gastrointestinal oncology
|July 12, 2024
概括
瘤间歇性成熟度显著影响结直肠癌的预后. 与成熟的肌瘤相比,不成熟的肌瘤与较差的无复发,无疾病和整体生存率有关.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 癌症研究 癌症研究
背景情况:
- 研究结直肠癌中瘤间歇性成熟的预后意义.
- 了解瘤筋膜在癌症进展和患者结局中的作用.
研究的目的:
- 检查间歇性成熟度与结直肠癌的预后之间的相关性.
- 评估不同程度的瘤间歇性成熟对生存结果的影响.
主要方法:
- 在PubMed,EMBASE,Cochrane图书馆,SpringerLink,CNKI和万芳数据库中进行全面的文献搜索,直到2023年12月.
- 使用审查经理对随机对照试验进行系统审查和元分析 5.2.2.
- 纳入标准侧重于评估瘤层成熟度,脱质反应和结直肠癌预后的研究.
主要成果:
- 分析了包括98949名结直肠癌患者在内的19项研究的数据.
- 不成熟和中间类型的肌瘤与与成熟的肌瘤相比,明显较低的无复发存活率,无疾病存活率和整体存活率有关.
- 危险比率表明,在较不成熟的流体中,不良结果的风险大幅增加.
结论:
- 瘤间歇性成熟度和结直肠癌生存预后之间存在显著的相关性.
- 瘤间歇性成熟度的程度会影响患者的生存率和潜在的生活质量.
- 瘤流体成熟度作为结直肠癌的潜在预后生物标志物.
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