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2型糖尿病是高性心肌病死亡的独立风险因素吗?
Said Hajouli1, Adam Belcher2, Frank Annie2
1Department of Cardiology, Charleston Area Medical Center, Charleston, WV, USA.
Cardiology research
|July 12, 2024
概括
2型糖尿病 (T2DM) 显著增加了心力衰竭和死亡的风险,在多变性心肌病 (HCM) 患者. 这项研究强调需要将T2DM视为HCM管理中的关键风险因素.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 过度缩性心肌病 (HCM) 的死亡率有所下降,但急性心脏病死亡 (SCD) 的危险因素需要持续评估.
- 目前对HCM风险分层的指导方针没有明确包括2型糖尿病 (T2DM),因为证据有限.
- T2DM是众所周知的各种心血管疾病的风险因素,促使对其在HCM结果中的作用进行调查.
研究的目的:
- 确定T2DM是否与HCM患者的5年不良结果风险增加有关,包括心力衰竭和全因死亡率.
- 评估T2DM对被诊断患有多变性心肌病的个体预后的影响.
主要方法:
- 从2018年1月1日到2023年3月1日,使用TrinetX数据库进行回顾性队列研究.
- 包括80,502名患有HCM的个人,分为有 (n=15,296) 和没有 (n=58,573) T2DM的队列.
- 进行了生存和风险分析,以评估5年全因死亡率和新发性心力衰竭发病率.
主要成果:
- 与没有T2DM的患者相比,患有T2DM的HCM患者的全因死亡率在统计学上显著增加.
- 在T2DM的HCM患者中观察到新发性心力衰竭的显著增加.
- 这些发现在调整主要心血管风险因素后仍然具有意义.
结论:
- 这项最大规模的研究之一,表明T2DM与HCM患者的不良结果之间存在显著的关联.
- 结果表明T2DM应该被认为是HCM的管理和风险分层的关键风险因素.
- 需要进一步的前性研究来阐明具体机制并证实这些发现.
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