在生物组织风湿学中不连续的剪切加厚
Michael J Hertaeg1, Suzanne M Fielding1, Dapeng Bi2
1Department of Physics, Durham University, Science Laboratories, South Road, Durham DH1 3LE, United Kingdom.
概括
这项研究模拟了二维的结合组织,以探索内部细胞应力和外部力量如何相互作用. 它揭示了复杂的质行为,如剪切加厚和屈服,为组织力学提供了洞察力.
科学领域:
- 生物物理学的生物物理.
- 软物质物理学 软物质物理学
- 发展生物学 发展生物学
背景情况:
- 胚胎发育和成人的组织功能取决于细胞承受机械应力并共同流动.
- 组织力学研究往往单独关注对外力或细胞内在活动的反应.
- 了解内部和外部力量之间的相互作用对于组织发育和平衡至关重要.
研究的目的:
- 为了研究全球外部变形和来自细胞运动的局部活性应力对二维交汇组织力学的综合影响.
- 为了阐明这种相互作用如何决定整个组织的新兴机械性质.
- 为了探索固体-流体阻塞过渡附近的质现象.
主要方法:
- 用一个活跃的顶点模型为2D交汇组织.
- 模拟了外部应用的全球变形和内部产生的局部活性应力之间的相互作用.
- 分析了在固体-液体阻塞/解阻塞过渡附近的组织行为.
主要成果:
- 观察到屈服,剪切薄化,连续剪切加厚,不连续剪切加厚.
- 证明了内部和外部力量的相互作用如何支配新出现的组织类风湿学.
- 确定了一系列令人着迷的风湿学现象.
结论:
- 活跃顶点模型为理解复杂组织类风湿学提供了一个框架.
- 模型预测与最近在体内观察到的非线性质行为保持一致.
- 这项工作弥合了单细胞活性过程和宏观组织力学之间的差距.
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