氧化指数和氧和指数用于预测紧急手术患者的术后结果:前性队列研究
Ruma Thakuria1, Emmanuel Easterson Ernest1, Apala Roy Chowdhury1
1Department of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India.
在接受紧急手术的成年人中,氧化指数 (OI) 和氧和指数 (OSI) 相对相关. 这些指标可以预测机械通风的需要和医院死亡率.
科学领域:
- 关键护理医学 关键护理医学
- 麻醉学 麻醉学
- 呼吸系统生理学 呼吸系统生理学
背景情况:
- 氧化指数 (OI) 已被用作儿童急性缺血性呼吸衰竭的预后工具.
- 以前,OI被确定为急性呼吸困扰综合征 (ARDS) 成年患者死亡率的独立预测因子.
研究的目的:
- 在接受紧急手术的成年患者中,评估氧化指数 (OI) 和氧和指数 (OSI) 之间的相关性.
- 评估OI和OSI的预后效用,以预测术后机械通风的需要和整体医院死亡率.
主要方法:
- 一项前性队列研究,涉及201名接受紧急手术的成年患者.
- 在多个时间点测量OI和OSI,包括手术前和手术后.
- 进行了统计分析,以确定OI和OSI之间的相关性,以及它们对通风和死亡率的预测准确性.
主要成果:
- 在手术前 (r2 = 0.61) 和手术后 (r2 = 0.47) 之间观察到OI和OSI之间存在显著的统计相关性.
- 对于入侵性呼吸器支持的要求,OSI表现出合理的预测准确性 (手术前AUROC:0.76;手术后AUROC:0.82).
- 与医院死亡率独立相关的因素包括年龄较大,总白血球数量较高,动脉乳酸盐升高和驾驶压力增加.
结论:
- 在接受全身麻醉紧急手术的成年患者中,OI和OSI是相关的.
- 无论是OI还是OSI,在预测24小时以后需要侵入性呼吸器支持和医院死亡率方面都表现出合理的准确性.
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