之前的SARS-CoV-2感染对结核病患者全身免疫反应的影响
Mariana S Xavier1, Mariana Araujo-Pereira2,3,4, Quezia M de Oliveira5
1Pós-graduação em Pesquisa Clínica em Doenças Infecciosas, Instituto Nacional de Infectologia Evandro Chagas, FIOCRUZ, Rio de Janeiro, Brazil.
Frontiers in immunology
|July 12, 2024
概括
以前的SARS-CoV-2感染结核病患者调节了免疫反应,显示出较低的全身炎症标志物和较少的发烧和呼吸不良等症状. 这种免疫调节在基线没有影响结核病的严重程度.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 呼吸系统医学 呼吸系统医学
背景情况:
- 以前感染过SARS-CoV-2的结核病 (TB) 患者的全身免疫反应仍然未被探索.
- 了解这种相互作用对于管理共感染至关重要.
研究的目的:
- 为了评估肺结核患者的全身免疫反应,有或没有先前的SARS-CoV-2感染.
- 识别免疫特征和临床表现的潜在差异.
主要方法:
- 在巴西里约热内卢进行的一项观察性,横截面的队列研究.
- 使用Luminex技术进行血细胞因子/化学因子/生长因子分析.
- 通过临床和实验室参数评估结核病的严重程度.
主要成果:
- 以前感染过SARS-CoV-2的肺结核患者 (TB/Prex-SCoV-2组) 显示了EGF,G-CSF,GM-CSF,IFN-α2,IL-12(p70),IL-13,IL-15,IL-17,IL-1β,IL-5,IL-7和TNF-β的血水平较低.
- 结核病/Prex-SCoV-2组表现出明显更高的MIP-1β水平.
- 结核病/Prex-SCoV-2组的发烧和呼吸障碍的发生频率较低,相比于没有先前感染SARS-CoV-2的结核病组.
结论:
- 之前的SARS-CoV-2感染诱导结核病患者的免疫调节,其特点是系统性炎症标志物减少.
- 这种免疫特征与发烧和呼吸障碍的发病率较低相关.
- 两组之间没有观察到基线结核病严重性参数的显著差异.
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