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通过高通量选发现了新型的结合剂,结合醇调节元素-结合蛋白-1 的新型结合剂

Takashi Maruyama1, Yu Takahashi1, Kahori Hiro1

  • 1Food Biochemistry Laboratory, Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.

ACS medicinal chemistry letters
|July 12, 2024
PubMed
概括

研究人员确定了两种化合物,它们与固醇调节元素结合蛋白-1 (SREBP-1) 结合,这是脂肪酸合成的关键因素. 这一发现可能会导致对肥胖和相关心血管疾病的新疗法.

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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...