片使用和胃肠道癌症:系统审查和元分析研究
Mahsa Mohammadi1, Philippe Tadger2, Amir Sadeghi3
1Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Guilan, Iran.
Gastroenterology and hepatology from bed to bench
|July 12, 2024
概括
片使用显著增加患胃肠道 (GI) 癌症的风险,包括口腔,胃,胰腺和结直肠类型. 这一发现强调了片的使用是这些常见恶性瘤的关键,可修改的危险因素.
科学领域:
- 胃肠道学和瘤学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 胃肠道 (GI) 恶性瘤是一个重大的全球健康挑战.
- 胃肠道癌的危险因素包括遗传倾向和生活方式选择.
- 片使用被认为是一种潜在的与生活方式有关的风险因素,需要进行调查.
研究的目的:
- 系统地审查和元分析片使用与胃肠道癌症风险之间的关联.
- 量化与各种片消费模式相关的整体和特定胃肠道恶性瘤的风险.
- 为公共卫生战略提供证据,以解决GI癌症预防中的可修改风险因素.
主要方法:
- 在主要的科学数据库 (PubMed,Web of Science,Embase,Scopus) 和波斯数据库 (Magiran,SID) 中进行了全面的搜索.
- 包括1983年至2022年间发表的相关研究,共计22篇文章.
- 使用随机效应模型进行了元分析,以对片使用和胃肠道癌症风险进行比率比率 (OR) 和95%置信区间 (CI).
主要成果:
- 片使用显著与胃肠道癌的风险增加有关 (原始OR:2.53;调整后OR:2.64).
- 与非使用相比,长时间使用 (OR:3.03),每日高剂量 (OR:3.41) 和高累计片使用 (OR:3.88) 的风险更高.
- 敏感性分析证实了研究结果的可靠性,并且没有发现显著的出版偏差.
结论:
- 片使用与整体肠胃癌和特定类型的高风险有关,包括口腔,胃,胰腺和结直肠癌.
- 鉴于片与癌症风险增加的关联,片使用应得到更多的关注,因为它可能是可修改的公共卫生问题.
- 公共卫生倡议应该考虑解决片使用问题,以减轻胃肠道癌症的负担.
相关概念视频
Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents
188
Diarrhea, a condition marked by frequent loose or watery bowel movements, can be triggered by multiple factors such as viral or bacterial infections, food intolerances, anxiety, medications, and digestive disorders. Symptoms may include abdominal pain, bloating, nausea, and cramping. Severe or prolonged diarrhea can lead to complications like electrolyte imbalances, malnutrition, and dehydration if left untreated.
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
188
Assessment of the Gastrointestinal System I: Subjective Data
171
Assessing the gastrointestinal (GI) system is a complex process that begins with collecting subjective data. This data, collected through patient interviews, provides crucial insights into the patient's health history, perception patterns, and lifestyle habits, all contributing significantly to GI health.
Health History
The initial step in assessing the GI system is obtaining a comprehensive health history. This includes inquiring about the patient's history or presence of problems...
Health History
The initial step in assessing the GI system is obtaining a comprehensive health history. This includes inquiring about the patient's history or presence of problems...
171
Analgesia and Pain Management
568
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
568
Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents
395
The gastric mucosa produces prostaglandins E2 (PGE2) and prostacyclin (PGI2), crucial in maintaining gastric health. They exert cytoprotective effects, including increasing bicarbonate secretion, releasing protective mucin, reducing gastric acid output, and preventing harmful vasoconstriction. These effects are mediated through various receptors, such as EP1, EP2, EP3, and EP4.
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
395
Opioid Analgesics: Morphine and Other Natural Cogeners
225
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
225


