患有非酒精性脂肪肝疾病的患者的怀孕结果:前性队列研究
Razieh Mohammad Jafari1, Elham Karimi Moghaddam2, Azar Ahmadzadeh2
1Fertility, Infertility and Perinatology Center, Imam Khomeini Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Gastroenterology and hepatology from bed to bench
|July 12, 2024
概括
患有非酒精性脂肪性肝病 (NAFLD) 的孕妇面临妊娠糖尿病和高血压的风险增加. 然而,NAFLD在本研究中没有显著影响婴儿出生体重或Apgar分数.
科学领域:
- 产科和妇科 产科和妇科
- 肝病学 肝病学是一种肝病学.
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 非酒精性脂肪肝 (NAFLD) 在全球范围内越来越令人担忧.
- 了解NAFLD对怀孕的影响对于母婴健康至关重要.
- 现有的关于NAFLD和怀孕结果的研究需要进一步调查.
研究的目的:
- 调查非酒精性脂肪性肝病 (NAFLD) 与孕产妇和周产期不良结果之间的关联.
- 为了确定与NAFLD相关的特定妊娠并发症.
- 评估NAFLD对产后婴儿健康指标的影响.
主要方法:
- 一项前性队列研究,涉及360名孕妇 (180名患有NAFLD,180名对照).
- 通过检查清单收集的数据,包括人口统计数据,病史和实验室结果.
- 评估到产后一周的妊娠结果;使用t测试和Chi-Square测试进行统计分析.
主要成果:
- 在NAFLD组表现出明显更高的妊娠糖尿病 (P<0.001) 和妊娠高血压 (P=0.003).
- 在NAFLD组中,ALT和AST水平的升高显著更为普遍 (P<0.001).
- 两组之间在妊娠年龄,产后出血,出生体重或Apgar分数方面没有发现显著差异.
结论:
- 患有NAFLD的孕妇患有妊娠期糖尿病,肝酶升高和高血压的风险增加.
- NAFLD似乎没有显著影响婴儿的关键结果,如出生体重或Apgar分数.
- 需要进一步的研究,以充分阐明NAFLD在怀孕中的长期影响.
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