谷蛋白摄入量与癌症风险之间的联系
Sajjad Bakhtiari1, Nastaran Asri2, Sepehr Maleki3
1Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Gastroenterology and hepatology from bed to bench
|July 12, 2024
概括
质消费可能会增加癌症风险,特别是在与质相关疾病 (GRDs) 患者中. 这项研究审查了质蛋白.
科学领域:
- 胃肠道学和瘤学
- 谷物科学与技术 谷物科学与技术
背景情况:
- 由于技术进步,谷物中的蛋白质混合物质越来越多地被消费.
- 质摄入量与敏感个体的质相关疾病 (GRD) 有关.
- 某些GRD与特定癌症的风险增加有关,包括结直肠癌和淋巴瘤.
研究的目的:
- 综合有关质暴露与癌症发病率之间的关联的当前知识.
- 调查一般人群和GRD患者之间的联系.
- 通过蛋白质-蛋白质相互作用 (PPI) 网络分析,探索乳病和癌症之间的共同遗传因素.
主要方法:
- 关于谷蛋白摄入量和癌症风险的文献综述.
- 对有关GRD和恶性瘤的流行病学数据的分析.
- 生物信息分析,包括PPI网络分析,用于病和癌症相关基因.
主要成果:
- 饮食中的谷蛋白摄入量是已知的消化系统癌症的可修改风险因素.
- 有证据表明,GRD与癌症风险增加之间存在相关性.
- 对PPI网络的分析发现了乳病和某些癌症之间的共同遗传途径.
结论:
- 暴露在质中是导致癌症发展的潜在因素,特别是在GRD患者中.
- 需要进一步的研究,以阐明与质,GRD和癌症相关的确切机制.
- 饮食管理和对GRD的认识对于降低癌症风险至关重要.
相关概念视频
Cancer Prevention
6.1K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.1K
Psychoneuroimmunology: Diabetes and Cancer
27
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
27
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
Cancer-Critical Genes I: Proto-oncogenes
8.8K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.8K
Cancers Originate from Somatic Mutations in a Single Cell
11.9K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
11.9K
Selectins
3.3K
Cell adhesion is an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain,...
3.3K


