生活质量和健康 膀癌中的国家公用事业 膀癌
Angela B Smith1,2, Sean McCabe2, Allison M Deal2
1Department of Urology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Bladder cancer (Amsterdam, Netherlands)
|July 12, 2024
概括
随着疾病的进展,膀癌患者的生活质量 (QOL) 显著下降. 从这项研究中获得的实用性得分可以帮助决策和膀癌护理的成本效益分析.
科学领域:
- 在瘤学瘤学.
- 医疗保健服务研究 医疗服务研究
- 患者报告的结果
背景情况:
- 膀癌治疗可以显著影响患者与健康相关的生活质量 (QOL).
- 了解疾病连续性的QOL对于全面的患者护理至关重要.
- 现有的数据可能无法完全捕捉从早期到晚期膀癌的QOL变化.
研究的目的:
- 综合评估膀癌患者的生活质量 (QOL).
- 在不同阶段描述QOL:非肌肉侵入性 (NMIBC),肌肉侵入性 (MIBC) 和转移性膀癌.
- 开发健康状态实用分数,用于膀癌护理中的成本效益分析.
主要方法:
- 通过膀癌倡导网络患者调查网络对911名膀癌患者进行横截面调查.
- 将患者分为NMIBC,MIBC或转移性健康状况.
- 利用通用线性混合模型来分析QOL,财务毒性和工作损害数据,推导出健康状态公用事业.
主要成果:
- 整体QOL和功能领域随着膀癌的进展而恶化.
- 工作和活动障碍从NMIBC显著增加到转移性疾病 (13%/12%至63%/31%).
- 具体的QOL缺陷包括MIBC中的肠道问题和转移性疾病中的尿路/身体功能;在MIBC和转移性组中,情绪功能较差.
结论:
- 随着膀癌的进展,与健康相关的生活质量 (QOL) 逐渐下降.
- 获得的健康状况实用性得分为共享决策提供了有价值的数据.
- 这些实用性估计可以为未来的经济评估和膀癌治疗的成本效益分析提供信息.
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