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肌肉侵入性膀癌中的血栓栓塞. 一个基于人口的全国性研究
Staffan Jahnson1, Truls Gårdmark2, Abolfazl Hosseini3
1Department of Clinical and Experimental Medicine, Division of Urology, Linköping University, Linköping, Sweden.
Bladder cancer (Amsterdam, Netherlands)
|July 12, 2024
概括
静脉血栓栓塞 (VTE) 在肌肉侵入性泌尿膀癌 (UBC) 患者中很常见,特别是在化疗和激进囊切除术 (RC) 后. 长期的VTE预防可能是有益的.
科学领域:
- 在瘤学瘤学.
- 血管医学 血管医学
- 流行病学 流行病学
背景情况:
- 静脉血栓塞栓症 (VTE) 预防在尿道癌 (UBC) 的激进囊切除术 (RC) 后是标准的.
- 随机或基于人群的研究对UBC患者的VTE风险的数据有限.
研究的目的:
- 调查肌肉侵入性UBC的VTE发生率和危险因素.
- 在UBC患者中评估VTE与激进囊切除术 (RC) 和化疗的相关性.
主要方法:
- 在全国范围内对9720名被诊断为T2-T4 UBC的患者进行了基于人口的研究,这些患者在1997-2014年被诊断为T2-T4 UBC.
- 利用了瑞典的膀癌数据库 (BladderBaSe),其中包括1987年VTE数据.
- 采用考克斯回归和卡普兰-梅尔分析来确定VTE风险因素和累积发病率.
主要成果:
- 5.6%的患者在诊断后经历了静脉瘤.
- 在调整混因子后,VTE与化学疗法相关,有或没有RC.
- 在诊断/治疗后的24个月内,静脉瘤发病率增加;之前的心血管疾病与较低的静脉瘤发病风险有关.
结论:
- 在肌肉侵袭性UBC患者中,特别是化学疗法后,VTE是一个重大问题.
- 这些发现支持对UBC幸存者的VTE预防疗效和安全性的长期干预研究的需要.
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