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营养状况作为多克索鲁比心脏毒性风险因素在墨西哥儿童急性淋巴细胞白血病

Jesús Alonso Gándara-Mireles^1,2, Ismael Lares-Asseff^1,2, Elio Aarón Reyes Espinoza³

¹Academia de Genómica, Instituto Politécnico Nacional, CIIDIR-Unidad Durango, México.

Nutrition and cancer

|July 12, 2024

概括

蛋白质热量营养不良 (PCM) 在患有急性淋巴细胞白血病 (ALL) 的儿童中显著增加了多克索鲁比诱导心脏毒性 (CT) 的风险. 健康的体重提供了对CT的保护,PCM的女孩表现出更高的易感性.

科学领域:

儿科瘤学儿科瘤学
心脏病学心脏病学
营养科学营养科学

背景情况:

急性淋巴细胞白血病 (ALL) 是全球流行的一种儿童癌症.
多克索鲁比 (Dox) 是ALL的关键化疗剂,但具有心脏毒性 (CT) 的风险.
蛋白质卡路里营养不良 (PCM) 是Dox诱导的CT的一个潜在因素.

研究的目的:

调查PCM与在墨西哥被诊断患有ALL的儿童中发展Dox诱导CT的风险之间的关联.
确定营养状况作为患有Dox治疗的儿科ALL患者心脏毒性风险因素.

主要方法:

分析了一组89名患有ALL的儿童,他们在2018年10月至2023年7月期间接受了Dox治疗.
评估了营养状况 (体重不足,健康体重,超重).
记录了CT的发病率,包括心和腹功能障碍,并根据营养状况进行了统计分析.

主要成果:

发现PCM与发展CT的风险增加之间存在统计学意义上的关联.
体重健康的儿童表现出对Dox诱导的CT的保护作用.
所有CT的女孩都表现出缩功能障碍;6人也患有腹缩功能障碍.
所有CT的男孩都患有缩功能障碍;一个男孩也患有腹缩功能障碍.

结论:

在患有ALL的儿童中,PCM是Dox诱导心脏毒性的重要危险因素.
保持健康的体重与这些患者对CT的保护有关.
患有PCM的女孩需要特别注意,因为缩功能障碍在CT发育中的前体作用.

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